David Watt

David is the Technical Director in the Business Development Department at WellSpring, and has over twenty years of pharmaceutical GMP experience in technical definition and evaluation of Contract Development and Manufacturing projects, both from provider and client perspectives. David has previously worked at Valeant, Medicis, Patheon and Syntex Pharmaceuticals. David is responsible for overseeing all technology transfer activities in the organization.
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Recent Posts

How to Maximize Pharmaceutical Manufacturing Quality From Your Employees

Posted by David Watt

In pharmaceutical manufacturing, a number of measurable factors affect quality. An organization can invest in state-of-the-art facilities, robust operating procedures and a sophisticated IT infrastructure, but it should also keep in mind that employees’ roles, responsibilities and the organizational structure play a large part in manufacturing success.

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Topics: pharmaceutical manufacturing, Corporate Culture, employee retention, quality

How to Use Pharmaceutical Manufacturing Metrics to Measure Quality

Posted by David Watt

In drug product manufacturing, quality is everything. Inconsistent quality can result in manufacturing delays, additional costs and a shortage of available products. Preventing and swiftly resolving any issues will benefit many stakeholders — including the client, the manufacturer and, ultimately, the end user of these products.

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Topics: quality, metrics, key performance indicators, best practices, compliance

Decision Time: Selecting a CMO Partner with Confidence

Posted by David Watt

If you are like most managers responsible for green-lighting a CMO partnership, making the decision to choose one supplier over another can be career changing. Making these decisions confidently depends on how well the selection process narrows the field of prospects to a manageable group of strong contenders.

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Topics: RFP, due diligence, CMO Partner

What is the Best Way to Develop an RFP?

Posted by David Watt

When a pharmaceutical company has a drug product and is in search of a contract manufacturing site to make its product, it usually puts out a request for proposals (RFP) to gather information regarding time, cost and the organization. While this might sound routine, the truth is that a mediocre, poorly organized RFP has the potential to slow the process of selecting the right manufacturer, drive up technology transfer and commercial product costs and also negatively impact the relationship between the sponsor and the manufacturer.

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Topics: ICH Q10, CMO, RFP

CMO Selection: Going from "Could Fit" To "Good Fit"

Posted by David Watt

Where does one start? For most drug owners seeking contract manufacturing support, it all depends on the type of product that they have. There’s always a set of established criteria, but there are a few other things for partner-seeking companies to look at, but it really depends on the mix and the philosophy of the organization, their cost sensitivity, price sensitivity, how aggressive they want to be, etc.

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Topics: Partner Relationships

Finding A Contract Manufacturing Partner That Fits

Posted by David Watt

Any journey of discovery begins with the first step and so it goes when seeking manufacturing and contract services partners. The likely goal of course is to find partners that “fit,” but getting to whatever constitutes a “good” fit relative to your organization is a process that one should start with a bit of introspection; sort of like “you can’t have a good relationship with someone else until you know who you really are first.”

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Topics: Partner Relationships

How Much Does It Cost To Make A Pharmaceutical Tablet Product?

Posted by David Watt

Pharmaceutical companies frequently ask us this question: how much does it cost to manufacture a pharmaceutical tablet? The real answer is: it depends on many factors. We need to truly understand the detailed specifics of the pharmaceutical company’s objectives and requirements for the product, with respect to manufacturing, packaging, testing, and regulatory submission in order for us to address cost in an intelligent and realistic manner.

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Topics: Manufacturing Scale-Up

5 Key Factors That Contribute To Price Differences Between Tablets And Creams In Drug Manufacturing

Posted by David Watt

Pharmaceutical companies frequently ask us this question when they have a multi-dosage form portfolio they want us to provide a quotation or scope of work on. The answer to this question is multi-faceted in that there are a number of questions with regard to materials, process, and testing requirements that need to answered.   

Armed with those answers, we can examine and factor the responses into a determination of the commercial cost to develop either a tablet or cream process.

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Topics: Manufacturing Scale-Up

What Product-Life Cycle Management Strategies Could Be Used To Extend The Life Of A Pharmaceutical Drug?

Posted by David Watt

Name brand (Innovator) pharmaceutical companies must extend the product life cycles of drugs to maintain profits, exclusivity, market share and transition into next generation products. Patent protection is crucial to the innovative pharmaceutical industry. Innovative companies require the guaranteed period of market exclusivity to sustain drug prices, recoup research and development costs and to fund the development of new products or next generation drugs.

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Topics: Quality & Regulatory

What Is The Difference Between a Glatt and a GEA-Niro Fluid Bed Granulator / Dryer?

Posted by David Watt

Many clients will come to us and have a specific type of fluid dryer that they’re using at their own facility or the facility at which they get their product manufactured. Typically, the fluid bed dryer will either be manufactured by Glatt or GEA Niro. A common client concern we address involves moving from one brand of FBG/FBD to another. The big question is – what are the main differences between these brands of equipment?

The correct answer is - there really is no difference between them. GEA Niro and Glatt are two different both world leading manufacturer’s of similar types of processing equipment for the production of powders, conglomerates and granulates. Basically, it’s more of a company preference than a performance choice.

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Topics: Manufacturing Scale-Up